PARD6A Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. Belongs to the PAR6 family. Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 16q22.1
Cellular Component:  bicellular tight junction; centriolar satellite; centrosome; cytosol; nucleus; plasma membrane; ruffle
Molecular Function:  GTP-dependent protein binding; protein binding; Rho GTPase binding; transcription factor binding
Biological Process:  bicellular tight junction assembly; cell division; cell-cell junction maintenance; centrosome cycle; negative regulation of protein phosphorylation; positive regulation of protein localization to centrosome; positive regulation of protein secretion; transforming growth factor beta receptor signaling pathway; viral process; Wnt signaling pathway, planar cell polarity pathway
Reference #:  Q9NPB6 (UniProtKB)
Alt. Names/Synonyms: PAR-6; PAR-6 alpha; par-6 family cell polarity regulator alpha; par-6 partitioning defective 6 homolog alpha; par-6 partitioning defective 6 homolog alpha (C. elegans); PAR-6A; PAR6; PAR6A; PAR6alpha; PAR6C; PARD6A; Partitioning defective 6 homolog alpha; partitioning defective-6 homolog alpha; partitioning-defective protein 6; Tax interaction protein 40; Tax-interacting protein 40; TAX40; TIP-40
Gene Symbols: PARD6A
Molecular weight: 37,388 Da
Basal Isoelectric point: 9.29  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Microtubule Dynamics  |  TGF-ß Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein