FEZ1 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. Belongs to the zygin family. Mainly expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 11q24.2
Cellular Component:  centrosome; dendrite; Golgi apparatus; growth cone; microtubule; mitochondrion; neuronal cell body; plasma membrane
Molecular Function:  gamma-tubulin binding; protein binding; protein kinase C binding; protein N-terminus binding
Biological Process:  axon guidance; cell adhesion; cellular response to growth factor stimulus; establishment of cell polarity; establishment of mitochondrion localization; hippocampus development; mitochondrion morphogenesis; negative regulation of autophagosome assembly; nervous system development; positive regulation of anterograde axonal transport of mitochondrion; positive regulation of neuron projection development
Reference #:  Q99689 (UniProtKB)
Alt. Names/Synonyms: fasciculation and elongation protein zeta 1; fasciculation and elongation protein zeta 1 (zygin I); Fasciculation and elongation protein zeta-1; FEZ1; UNC-76; Zygin I; Zygin-1
Gene Symbols: FEZ1
Molecular weight: 45,119 Da
Basal Isoelectric point: 4.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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