EAF1 Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Belongs to the EAF family. Strongly expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine and colon. Poorly expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of human Ortholog: 3p25.1
Cellular Component:  Cajal body; ELL-EAF complex; intercellular bridge; intracellular membrane-bounded organelle; nuclear body; nuclear speck; nucleoplasm; transcription elongation factor complex
Molecular Function:  protein binding
Biological Process:  regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter
Reference #:  Q96JC9 (UniProtKB)
Alt. Names/Synonyms: EAF1; ELL (eleven nineteen lysine-rich leukemia gene)-associated factor 1; ELL associated factor 1; ELL-associated factor 1
Gene Symbols: EAF1
Molecular weight: 29,042 Da
Basal Isoelectric point: 5.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB