CHMP7 ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway. Belongs to the SNF7 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 8p21.3
Cellular Component:  cytosol; ESCRT III complex; nuclear envelope; nucleus
Molecular Function:  protein binding
Biological Process:  endosomal transport; ESCRT III complex disassembly; exit from mitosis; late endosome to vacuole transport; midbody abscission; mitotic metaphase plate congression; multivesicular body assembly; nuclear envelope reassembly; nucleus organization; protein localization to chromatin; protein transport; viral budding via host ESCRT complex; viral life cycle
Reference #:  Q8WUX9 (UniProtKB)
Alt. Names/Synonyms: Charged multivesicular body protein 7; CHMP family, member 7; CHMP7; Chromatin-modifying protein 7; MGC29816
Gene Symbols: CHMP7
Molecular weight: 50,911 Da
Basal Isoelectric point: 5.26  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB