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PTBP2
RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5 has a reduced affinity for RNA. Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; RNA-binding |
| Chromosomal Location of Human Ortholog: 1p21.3 |
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Cellular Component:
growth cone; neuronal cell body; spliceosomal complex
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Molecular Function:
mRNA binding
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Biological Process:
cerebellum development; mRNA splice site selection; negative regulation of RNA splicing; regulation of neural precursor cell proliferation; spinal cord development
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Reference #:
Q9UKA9
(UniProtKB)
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Alt. Names/Synonyms: brPTB; FLJ34897; neural polypyrimidine tract binding protein; Neural polypyrimidine tract-binding protein; Neurally-enriched homolog of PTB; NPTB; nPTB5; nPTB6; nPTB7; nPTB8; polypyrimidine tract binding protein 2; Polypyrimidine tract-binding protein 2; PTB; PTB-like protein; PTBLP; PTBP2; splicing regulator
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Gene Symbols: PTBP2
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Molecular weight:
57,491 Da
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Basal Isoelectric point:
8.72
Predict pI for various phosphorylation states
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