FAM123A Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Belongs to the Amer family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 13q12.13
Cellular Component:  plasma membrane
Molecular Function:  phosphatidylinositol-4,5-bisphosphate binding; protein binding
Biological Process:  ectoderm development; negative regulation of canonical Wnt signaling pathway; Wnt signaling pathway
Reference #:  Q8N7J2 (UniProtKB)
Alt. Names/Synonyms: AMER2; APC membrane recruitment protein 2; F123A; FAM123A; family with sequence similarity 123A; FLJ25477; hypothetical protein LOC219287; Protein FAM123A
Gene Symbols: AMER2
Molecular weight: 69,507 Da
Basal Isoelectric point: 6.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein