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FAM123A
Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Belongs to the Amer family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 13q12.13 |
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Cellular Component:
plasma membrane
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Molecular Function:
beta-catenin binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding
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Biological Process:
ectoderm development; negative regulation of canonical Wnt signaling pathway; regulation of canonical Wnt signaling pathway; Wnt signaling pathway
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Reference #:
Q8N7J2
(UniProtKB)
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Alt. Names/Synonyms: AMER2; APC membrane recruitment protein 2; F123A; FAM123A; family with sequence similarity 123A; FLJ25477; hypothetical protein LOC219287; Protein FAM123A
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Gene Symbols: AMER2
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Molecular weight:
69,507 Da
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Basal Isoelectric point:
6.55
Predict pI for various phosphorylation states
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