APOOL Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function,. Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family. Note: This description may include information from UniProtKB.
Protein type: Mitochondrial; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xq21.1
Cellular Component:  extracellular region; MICOS complex; mitochondrion; platelet alpha granule lumen
Molecular Function:  protein binding
Biological Process:  platelet degranulation
Reference #:  Q6UXV4 (UniProtKB)
Alt. Names/Synonyms: AAIR8193; apolipoprotein O like; Apolipoprotein O-like; APOOL; CXorf33; FAM121A; family with sequence similarity 121A; MGC129748; MIC27; MICOS complex subunit MIC27; MICOS27; mitochondrial contact site and cristae organizing system subunit 27; Protein FAM121A; UNQ8193
Gene Symbols: APOOL
Molecular weight: 29,159 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene