ARFGEF3 a single-pass membrane protein. Promotes the activation of ARF G-proteins through replacement of GDP with GTP. Four alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, ARF; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q23.3-q24.1
Cellular Component:  integral component of membrane; transport vesicle membrane
Molecular Function:  ARF guanyl-nucleotide exchange factor activity
Biological Process:  negative regulation of phosphatase activity; regulation of ARF protein signal transduction
Reference #:  Q5TH69 (UniProtKB)
Alt. Names/Synonyms: A7322; ARFGEF3; BIG3; Brefeldin A-inhibited guanine nucleotide-exchange protein 3; C6orf92; dJ171N11.1; FLJ32064; KIAA1244
Gene Symbols: ARFGEF3
Molecular weight: 240,652 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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