LRMP
Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Belongs to the LRMP family. Expressed at high levels in pre B-cells, mature B-cells and pre T-cells. Expressed at low levels in mature T-cells and plasma B-cells. Expressed in germinal center B-cells, splenic marginal zone cells and B-cell lymphomas. Expressed in neuronal cells in the cerebral cortex, epithelial cells in tonsil, adrenal glands, zymogen-producing cells in the stomach and epithelial cells in seminal vesicles. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Chromosomal Location of human Ortholog: 12p12.1 |
Cellular Component:
azurophil granule membrane; chromosome; endoplasmic reticulum membrane; microtubule organizing center; nuclear envelope; plasma membrane; spindle pole
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Molecular Function:
microtubule binding
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Biological Process:
immune system process; nucleus organization; single fertilization; vesicle fusion; vesicle targeting
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Reference #:
Q12912
(UniProtKB)
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Alt. Names/Synonyms: Inositol 1,4,5-triphosphate receptor associated 2; IRAG2; JAW1; LRMP; lymphoid restricted membrane protein; Lymphoid-restricted membrane protein; Processed inositol 1,4,5-triphosphate receptor associated 2; Processed lymphoid-restricted membrane protein; Protein Jaw1
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Gene Symbols: IRAG2
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Molecular weight:
62,122 Da
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Basal Isoelectric point:
5.62
Predict pI for various phosphorylation states
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