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PDE1B
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; EC 3.1.4.17; Nucleotide Metabolism - purine; Phosphodiesterase |
| Chromosomal Location of human Ortholog: 12q13.2 |
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Cellular Component:
cytosol; neuronal cell body
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Molecular Function:
3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin binding; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding; protein binding
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Biological Process:
cellular response to granulocyte macrophage colony-stimulating factor stimulus; cellular response to macrophage colony-stimulating factor stimulus; locomotory behavior; monocyte differentiation; regulation of dopamine metabolic process; regulation of neurotransmitter levels; response to amphetamine; serotonin metabolic process; signal transduction; visual learning
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Reference #:
Q01064
(UniProtKB)
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Alt. Names/Synonyms: 63 kDa Cam-PDE; Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; Cam-PDE 1B; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; epididymis secretory sperm binding protein Li 79p; HEL-S-79p; PDE1B; PDE1B1; PDES1B; phosphodiesterase 1B; phosphodiesterase 1B, calmodulin-dependent; phosphodiesterase IB, calmodulin-dependent; Phosphodiesterase-1B; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
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Gene Symbols: PDE1B
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Molecular weight:
61,380 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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