MYBPC1 Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Myosin-binding
Chromosomal Location of Human Ortholog: 12q23.2
Cellular Component:  cytosol; myofibril; myosin filament
Molecular Function:  protein binding; titin binding
Biological Process:  cell adhesion; muscle filament sliding
Disease: Arthrogryposis, Distal, Type 1b; Lethal Congenital Contracture Syndrome 4; Myopathy, Congenital, With Tremor
Reference #:  Q00872 (UniProtKB)
Alt. Names/Synonyms: C-protein, skeletal muscle slow isoform; MYBPC1; MYBPCC; MYBPCS; myosin binding protein C, slow type; Myosin-binding protein C, slow-type; MYPC1; skeletal muscle C-protein; Slow MyBP-C; slow-type
Gene Symbols: MYBPC1
Molecular weight: 128,294 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
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MYBPC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein