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MYBPC1
Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Myosin-binding |
| Chromosomal Location of human Ortholog: 12q23.2 |
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Cellular Component:
cytosol; myofibril; myosin filament
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Molecular Function:
actin binding; myosin binding; protein binding; structural constituent of muscle; titin binding
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Biological Process:
cell adhesion
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Disease: Arthrogryposis, Distal, Type 1b; Lethal Congenital Contracture Syndrome 4; Myopathy, Congenital, With Tremor
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Reference #:
Q00872
(UniProtKB)
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Alt. Names/Synonyms: C-protein, skeletal muscle slow isoform; LCCS4; MYBPC1; MYBPCC; MYBPCS; myosin binding protein C, slow type; myosin binding protein C1; Myosin-binding protein C, slow-type; MYOTREM; MYPC1; skeletal muscle C-protein; Slow MyBP-C; slow skeletal-type muscle myosin-binding-protein C; slow-type; ssMyBP-C
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Gene Symbols: MYBPC1
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Molecular weight:
128,294 Da
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Basal Isoelectric point:
5.78
Predict pI for various phosphorylation states
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