IDH3G Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Belongs to the isocitrate and isopropylmalate dehydrogenases family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.41; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: Xq28
Cellular Component:  mitochondrial matrix; mitochondrion; nucleolus; nucleoplasm
Molecular Function:  ATP binding; isocitrate dehydrogenase (NAD+) activity; magnesium ion binding; NAD binding
Biological Process:  carbohydrate metabolic process; isocitrate metabolic process; tricarboxylic acid cycle
Reference #:  P51553 (UniProtKB)
Alt. Names/Synonyms: H-IDHG; IDH-gamma; IDH3G; isocitrate dehydrogenase 3 (NAD+) gamma; Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial; isocitrate dehydrogenase, NAD(+)-specific, mitochondrial, gamma subunit; Isocitric dehydrogenase subunit gamma; NAD (H)-specific isocitrate dehydrogenase gamma subunit; NAD(+)-specific ICDH subunit gamma; NAD+-specific ICDH
Gene Symbols: IDH3G
Molecular weight: 42,794 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
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IDH3G

Protein Structure Not Found.


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