HAAO Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. Belongs to the 3-HAO family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.6; Oxidoreductase
Chromosomal Location of human Ortholog: 2p21
Cellular Component:  cytosol
Molecular Function:  3-hydroxyanthranilate 3,4-dioxygenase activity; electron transfer activity; ferrous iron binding; protein binding
Biological Process:  anthranilate metabolic process; electron transport chain; NAD biosynthetic process; neuron cellular homeostasis; quinolinate biosynthetic process; response to cadmium ion; response to zinc ion; tryptophan catabolic process
Disease: Vertebral, Cardiac, Renal, And Limb Defects Syndrome 1
Reference #:  P46952 (UniProtKB)
Alt. Names/Synonyms: 3-HAO; 3-hydroxyanthranilate 3,4-dioxygenase; 3-hydroxyanthranilate oxygenase; 3-hydroxyanthranilic acid dioxygenase; 3HAO; h3HAO; HAAO; HAD; HAO; VCRL1
Gene Symbols: HAAO
Molecular weight: 32,556 Da
Basal Isoelectric point: 5.62  Predict pI for various phosphorylation states
Select Structure to View Below

HAAO

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene