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USP5
Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition. Belongs to the peptidase C19 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.19.12; Protease; Ubiquitin-specific protease |
| Chromosomal Location of human Ortholog: 12p13.31 |
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Cellular Component:
cytosol; lysosome; nucleus
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Molecular Function:
cysteine-type deubiquitinase activity; protein binding; ubiquitin binding; zinc ion binding
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Biological Process:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; protein K48-linked deubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process
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Reference #:
P45974
(UniProtKB)
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Alt. Names/Synonyms: Deubiquitinating enzyme 5; Isopeptidase T; ISOT; testicular tissue protein Li 218; Ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific peptidase 5; ubiquitin specific peptidase 5 (isopeptidase T); ubiquitin specific protease 5 (isopeptidase T); Ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); Ubiquitin-specific-processing protease 5; UBP5; USP5
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Gene Symbols: USP5
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Molecular weight:
95,786 Da
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Basal Isoelectric point:
4.91
Predict pI for various phosphorylation states
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