USP8 Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-medaited APP cleavage and amyloid-beta formation. Belongs to the peptidase C19 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease
Chromosomal Location of human Ortholog: 15q21.2
Cellular Component:  cytoplasm; cytosol; early endosome; extrinsic component of plasma membrane; glutamatergic synapse; midbody; nucleus
Molecular Function:  cysteine-type endopeptidase activity; protein binding; SH3 domain binding; thiol-dependent ubiquitin-specific protease activity
Biological Process:  cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; endosome organization; mitotic cytokinesis; positive regulation of canonical Wnt signaling pathway; protein deubiquitination; protein K48-linked deubiquitination; protein K63-linked deubiquitination; regulation of protein catabolic process at postsynapse, modulating synaptic transmission; regulation of protein localization; regulation of protein stability; ubiquitin-dependent protein catabolic process
Disease: Pituitary Adenoma, Acth-secreting
Reference #:  P40818 (UniProtKB)
Alt. Names/Synonyms: Deubiquitinating enzyme 8; FLJ34456; hUBPy; HumORF8; KIAA0055; MGC129718; PITA4; SPG59; Ubiquitin carboxyl-terminal hydrolase 8; Ubiquitin isopeptidase Y; ubiquitin specific peptidase 8; ubiquitin specific protease 8; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; Ubiquitin-specific-processing protease 8; UBP8; UBPY; USP8
Gene Symbols: USP8
Molecular weight: 127,523 Da
Basal Isoelectric point: 8.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein