CTNNA2 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Required for proper regulation of cortical neuronal migration and neurite growth. It acts as negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. Belongs to the vinculin/alpha-catenin family. Expressed in neural tissues, with strongest expression in fetal and adult brain. Expressed in the developing cortical plate and marginal zone of 20-week-old human fetal brain. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cancer Testis Antigen (CTA); Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p12
Cellular Component:  actin cytoskeleton; adherens junction; axon; basolateral plasma membrane; cell-cell adherens junction; cytoplasm; cytosol; extrinsic component of postsynaptic membrane; extrinsic component of presynaptic membrane; hippocampal mossy fiber to CA3 synapse; lamellipodium; nucleus; parallel fiber to Purkinje cell synapse; postsynaptic density, intracellular component; presynaptic active zone cytoplasmic component
Molecular Function:  actin filament binding; identical protein binding; protein binding; structural constituent of cytoskeleton
Biological Process:  axonogenesis; brain morphogenesis; cell-cell adhesion; cytoskeleton organization; dendrite morphogenesis; modification of postsynaptic actin cytoskeleton; negative regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of muscle cell differentiation; prepulse inhibition; radial glia guided migration of Purkinje cell; regulation of neuron migration; regulation of neuron projection development; regulation of synapse structural plasticity
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 9
Reference #:  P26232 (UniProtKB)
Alt. Names/Synonyms: Alpha N-catenin; Alpha-catenin-related protein; alpha-N-catenin; cadherin-associated protein, related; cancer/testis antigen 114; CAP-R; CAPR; catenin (cadherin-associated protein), alpha 2; catenin alpha 2; Catenin alpha-2; CDCBM9; CT 114; CT114; CTNA2; CTNNA2; CTNR; DKFZp686H02198
Gene Symbols: CTNNA2
Molecular weight: 105,313 Da
Basal Isoelectric point: 5.52  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CTNNA2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein