XPA Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Belongs to the XPA family. Expressed in various cell lines and in skin fibroblasts. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.33
Cellular Component:  cytoplasm; intercellular bridge; nucleoplasm; nucleus
Molecular Function:  damaged DNA binding; metal ion binding; protein binding; protein domain specific binding; protein homodimerization activity
Biological Process:  DNA repair; global genome nucleotide-excision repair; intrinsic apoptotic signaling pathway in response to DNA damage; multicellular organism growth; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision; nucleotide-excision repair, DNA incision, 3'-to lesion; nucleotide-excision repair, DNA incision, 5'-to lesion; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, preincision complex stabilization; protein localization to nucleus; regulation of autophagy; response to auditory stimulus; response to oxidative stress; response to toxic substance; transcription-coupled nucleotide-excision repair; UV protection
Disease: Xeroderma Pigmentosum, Complementation Group A
Reference #:  P23025 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein complementing XP-A cells; excision repair-controlling; Xeroderma pigmentosum group A-complementing protein; xeroderma pigmentosum, complementation group A; XP1; XPA; XPAC
Gene Symbols: XPA
Molecular weight: 31,368 Da
Basal Isoelectric point: 6.29  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene