EDG-1 a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 1p21.2
Cellular Component:  endosome; external side of plasma membrane; integral component of membrane; intracellular membrane-bounded organelle; intrinsic component of plasma membrane; membrane raft; nucleoplasm; plasma membrane
Molecular Function:  G protein-coupled receptor activity; G protein-coupled receptor binding; protein binding; sphingolipid binding; sphingosine-1-phosphate receptor activity
Biological Process:  actin cytoskeleton reorganization; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; angiogenesis; blood vessel maturation; brain development; cardiac muscle tissue growth involved in heart morphogenesis; cell adhesion; cell migration; chemotaxis; cytokine-mediated signaling pathway; endothelial cell differentiation; G protein-coupled receptor signaling pathway; heart trabecula morphogenesis; lamellipodium assembly; leukocyte chemotaxis; negative regulation of stress fiber assembly; neuron differentiation; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of GTPase activity; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of bone mineralization; regulation of bone resorption; regulation of cell adhesion; sphingosine-1-phosphate receptor signaling pathway; T cell migration; transmission of nerve impulse
Reference #:  P21453 (UniProtKB)
Alt. Names/Synonyms: CHEDG1; D1S3362; ECGF1; EDG-1; EDG1; Endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; FLJ58121; S1P receptor 1; S1P receptor Edg-1; S1P1; S1PR1; Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine-1-phosphate receptor 1
Gene Symbols: S1PR1
Molecular weight: 42,811 Da
Basal Isoelectric point: 9.59  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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