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RTN2
Isoform RTN2-C is highly expressed in skeletal muscle. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 19q13.32 |
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Cellular Component:
cell surface; endoplasmic reticulum; endoplasmic reticulum membrane; intermediate filament; sarcoplasmic reticulum membrane; T-tubule; terminal cisterna; Z disc
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Molecular Function:
protein binding
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Biological Process:
gene expression; intracellular protein transmembrane transport; negative regulation of amyloid-beta formation; regulation of glucose import
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Disease: Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 11, With Spasticity; Spastic Paraplegia 12, Autosomal Dominant
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Reference #:
O75298
(UniProtKB)
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Alt. Names/Synonyms: Neuroendocrine-specific protein-like 1; Neuroendocrine-specific protein-like I; NSP-like protein 1; NSP-like protein I; NSP2; NSPL1; NSPLI; reticulon 2; Reticulon-2; RTN2; SPG12
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Gene Symbols: RTN2
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Molecular weight:
59,264 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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