EEF1A1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation elongation
Cellular Component: 
Reference #:  P68105 (UniProtKB)
Alt. Names/Synonyms: eEF1A-1; EEF1A1; EF-1-alpha-1; EF-Tu; EF1A1; elongation factor 1 A-1; Elongation factor 1-alpha 1; elongation factor Tu
Gene Symbols: RABEFLA2
Molecular weight: 50,141 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
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EEF1A1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene