MPDZ Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q31
Cellular Component:  apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cytoplasm; cytoplasmic vesicle; dendrite; endomembrane system; postsynaptic density; postsynaptic membrane; Schmidt-Lanterman incisure
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  cell adhesion; intracellular signal transduction; myelination
Reference #:  O55164 (UniProtKB)
Alt. Names/Synonyms: Mpdz; Multi-PDZ domain protein 1; Multiple PDZ domain protein; Mupp1
Gene Symbols: Mpdz
Molecular weight: 218,592 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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MPDZ

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene