MPDZ interacts with HTR2C (serotonin receptor 2C) and provokes its clustering at the cell surface. Member of the NMDAR signaling complex and may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Highly enriched in postsynaptic densities (PSD). Localized to punctae on dendrites of hippocampal neurons and colocalizes with the synaptic marker PSD-95. Localized mainly in the Schmidt-Lanterman incisures of myelinating Schwann cells. In the retina, localizes to the sub-apical region adjacent to the adherens junction complex at the outer limiting membrane. Enriched at the tight junctions of epithelial cells. Association to the tight junctions depends on CXADR. Contains 13 PDZ domains. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 5q31
Cellular Component:  apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cytoplasm; cytoplasmic vesicle; dendrite; endomembrane system; postsynaptic density; postsynaptic membrane; Schmidt-Lanterman incisure
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  cell adhesion; intracellular signal transduction; myelination
Reference #:  O55164 (UniProtKB)
Alt. Names/Synonyms: Mpdz; Multi-PDZ domain protein 1; Multiple PDZ domain protein; Mupp1
Gene Symbols: Mpdz
Molecular weight: 218,592 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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MPDZ

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene