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MPDZ
Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of rat Ortholog: 5q31 |
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Cellular Component:
apical part of cell; apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cytoplasm; cytoplasmic vesicle; dendrite; endomembrane system; glutamatergic synapse; plasma membrane; postsynaptic density; Schmidt-Lanterman incisure; subapical complex; synapse
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Molecular Function:
protein binding
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Biological Process:
cell adhesion; dendrite development; intracellular protein transport; intracellular signal transduction; microtubule organizing center organization; myelination; regulation of microtubule cytoskeleton organization; tight junction assembly
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Reference #:
O55164
(UniProtKB)
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Alt. Names/Synonyms: Mpdz; Multi-PDZ domain protein 1; Multiple PDZ domain protein; Mupp1
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Gene Symbols: Mpdz
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Molecular weight:
218,592 Da
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Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
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