WASP Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: Xp11.23
Cellular Component:  actin cytoskeleton; actin filament; cell-cell junction; cytosol; nucleus; phagocytic vesicle; site of double-strand break; vesicle membrane
Molecular Function:  GTPase regulator activity; identical protein binding; phospholipase binding; protein binding; protein kinase binding; Rac GTPase binding; SH3 domain binding; small GTPase binding
Biological Process:  actin filament polymerization; actin polymerization or depolymerization; blood coagulation; Cdc42 protein signal transduction; cellular response to interferon-gamma; defense response; endosomal transport; epidermis development; Fc-gamma receptor signaling pathway involved in phagocytosis; immune response; negative regulation of cell motility; negative regulation of stress fiber assembly; positive regulation of Arp2/3 complex-mediated actin nucleation; positive regulation of double-strand break repair via homologous recombination; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; regulation of actin polymerization or depolymerization; regulation of catalytic activity; regulation of lamellipodium assembly; regulation of stress fiber assembly; regulation of T cell antigen processing and presentation; T cell activation; T cell receptor signaling pathway
Disease: Neutropenia, Severe Congenital, X-linked; Thrombocytopenia 1; Wiskott-aldrich Syndrome
Reference #:  P42768 (UniProtKB)
Alt. Names/Synonyms: eczema-thrombocytopenia; IMD2; SCNX; THC; THC1; thrombocytopenia 1 (X-linked); WAS; WASp; WASP actin nucleation promoting factor; WASPA; Wiskott-Aldrich syndrome (eczema-thrombocytopenia); Wiskott-Aldrich syndrome protein
Gene Symbols: WAS
Molecular weight: 52,913 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene