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MPDZ
Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of Human Ortholog: 4 C3|4 38.0 cM |
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Cellular Component:
apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cell junction; cell projection; cytoplasm; cytoplasmic vesicle; membrane; neuron projection; plasma membrane; postsynaptic membrane; Schmidt-Lanterman incisure; synapse
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Molecular Function:
protein binding; protein C-terminus binding
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Biological Process:
cell adhesion; myelination
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Reference #:
Q8VBX6
(UniProtKB)
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Alt. Names/Synonyms: AI225843; B930003D11Rik; Mpdz; Multi-PDZ domain protein 1; multiple PDZ domain crumbs cell polarity complex component; Multiple PDZ domain protein; MUP; Mupp1; OTTMUSP00000000753; RP23-59O12.1
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Gene Symbols: Mpdz
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Molecular weight:
218,711 Da
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Basal Isoelectric point:
4.9
Predict pI for various phosphorylation states
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