MPDZ Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 9p23
Cellular Component:  apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cytoplasm; cytoplasmic vesicle; dendrite; postsynaptic density; postsynaptic membrane; Schmidt-Lanterman incisure
Molecular Function:  protein binding; protein C-terminus binding
Biological Process:  cell adhesion; viral process
Disease: Hydrocephalus, Nonsyndromic, Autosomal Recessive 2
Reference #:  O75970 (UniProtKB)
Alt. Names/Synonyms: DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; HYC2; MPDZ; Multi-PDZ domain protein 1; multiple PDZ domain crumbs cell polarity complex component; Multiple PDZ domain protein; MUPP1
Gene Symbols: MPDZ
Molecular weight: 221,618 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene