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MPDZ
Interacts with HTR2C and provokes its clustering at the cell surface. Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 9p23 |
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Cellular Component:
apical part of cell; apical plasma membrane; apicolateral plasma membrane; bicellular tight junction; cytoplasm; dendrite; plasma membrane; postsynaptic density
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Molecular Function:
protein binding
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Biological Process:
microtubule organizing center organization; regulation of microtubule cytoskeleton organization; tight junction assembly
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Disease: Hydrocephalus, Nonsyndromic, Autosomal Recessive 2
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Reference #:
O75970
(UniProtKB)
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Alt. Names/Synonyms: DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; HYC2; MPDZ; Multi-PDZ domain protein 1; multiple PDZ domain crumbs cell polarity complex component; Multiple PDZ domain protein; MUPP1
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Gene Symbols: MPDZ
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Molecular weight:
221,618 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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