FBW1B Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis. Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2. (Microbial infection) Target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of human Ortholog: 5q35.1
Cellular Component:  centrosome; cytosol; nucleus; SCF ubiquitin ligase complex; ubiquitin ligase complex
Molecular Function:  protein binding; protein dimerization activity; ubiquitin-protein transferase activity
Biological Process:  Fc-epsilon receptor signaling pathway; G2/M transition of mitotic cell cycle; interleukin-1-mediated signaling pathway; negative regulation of NIK/NF-kappaB signaling; negative regulation of transcription, DNA-templated; NIK/NF-kappaB signaling; positive regulation of circadian rhythm; positive regulation of proteolysis; positive regulation of transcription, DNA-templated; post-translational protein modification; proteasome-mediated ubiquitin-dependent protein catabolic process; protein dephosphorylation; protein destabilization; protein polyubiquitination; protein ubiquitination; rhythmic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; Wnt signaling pathway
Disease: Neurodevelopmental, Jaw, Eye, And Digital Syndrome
Reference #:  Q9UKB1 (UniProtKB)
Alt. Names/Synonyms: beta-transducin repeat-containing protein 2; BTRC2; BTRCP2; F-box and WD repeat domain containing 11; F-box and WD repeats protein beta-TrCP2; F-box and WD-40 domain protein 11; F-box and WD-40 domain protein 1B; F-box protein Fbw1b; F-box/WD repeat-containing protein 11; F-box/WD repeat-containing protein 1B; Fbw11; FBW1B; FBXW11; FBXW1B; Homologous to Slimb protein; HOS; KIAA0696; NEDJED
Gene Symbols: FBXW11
Molecular weight: 62,091 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein