CD99L2 Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Homophilic adhesion molecule, but these interactions may not be required for cell aggregation. Belongs to the CD99 family. Expressed in many tissues, with low expression in thymus. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of human Ortholog: Xq28
Cellular Component:  cell surface; cell-cell adherens junction; integral component of membrane; plasma membrane
Molecular Function:  protein binding
Biological Process:  cell adhesion; diapedesis; positive regulation of neutrophil extravasation; positive regulation of T cell extravasation
Reference #:  Q8TCZ2 (UniProtKB)
Alt. Names/Synonyms: C99L2; CD99; CD99 antigen-like 2; CD99 antigen-like protein 2; CD99 molecule like 2; CD99 molecule-like 2; CD99B; CD99L2; DKFZp761H2024; MIC2 like 1; MIC2-like protein 1; MIC2L1; Xap89
Gene Symbols: CD99L2
Molecular weight: 27,986 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
Select Structure to View Below

CD99L2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein