NFI-B Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Belongs to the CTF/NF-I family. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9p23-p22.3
Cellular Component:  cerebellar mossy fiber; fibrillar center; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding
Biological Process:  anterior commissure morphogenesis; cell differentiation involved in salivary gland development; chondrocyte differentiation; Clara cell differentiation; commissural neuron axon guidance; DNA replication; glial cell differentiation; hindbrain development; lung ciliated cell differentiation; negative regulation of epithelial cell proliferation involved in lung morphogenesis; negative regulation of mesenchymal cell proliferation involved in lung development; negative regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; principal sensory nucleus of trigeminal nerve development; response to bacterium; salivary gland cavitation; type I pneumocyte differentiation; type II pneumocyte differentiation
Disease: Macrocephaly, Acquired, With Impaired Intellectual Development
Reference #:  O00712 (UniProtKB)
Alt. Names/Synonyms: CCAAT-box-binding transcription factor; CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB; NFIB2; NFIB3; Nuclear factor 1 B-type; Nuclear factor 1/B; nuclear factor I B; Nuclear factor I/B; TGGCA-binding protein
Gene Symbols: NFIB
Molecular weight: 47,442 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene