KIF2A Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 5q12.1
Cellular Component:  centriolar subdistal appendage; centriole; centrosome; cytoplasm; cytosol; nuclear body; nucleolus; nucleus; sperm principal piece
Molecular Function:  ATP binding; microtubule binding; motor activity; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cell differentiation; cell division; microtubule cytoskeleton organization; microtubule depolymerization; microtubule-based movement; mitotic spindle assembly; mitotic spindle organization; nervous system development; regulation of cell migration; retrograde vesicle-mediated transport, Golgi to ER
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 3
Reference #:  O00139 (UniProtKB)
Alt. Names/Synonyms: hK2; KIF2; KIF2A; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; Kinesin-2; Kinesin-like protein KIF2A; KNS2
Gene Symbols: KIF2A
Molecular weight: 79,955 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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