ARRB1 iso2 an arrestin protein of the beta-arrestin protein family that function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating receptor desensitization. Also play roles in receptor resensitization processes. Acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 11q13.4
Cellular Component:  basolateral plasma membrane; chromatin; clathrin-coated pit; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytosol; dendritic spine; endosome; Golgi membrane; lysosomal membrane; nuclear body; nucleoplasm; nucleus; plasma membrane; postsynaptic density; postsynaptic membrane; pseudopodium
Molecular Function:  alpha-1A adrenergic receptor binding; alpha-1B adrenergic receptor binding; angiotensin receptor binding; AP-2 adaptor complex binding; arrestin family protein binding; clathrin adaptor activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; enzyme inhibitor activity; estrogen receptor binding; follicle-stimulating hormone receptor binding; GTPase activator activity; insulin-like growth factor receptor binding; ion channel binding; mitogen-activated protein kinase kinase binding; protein binding; protein phosphorylated amino acid binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding; V2 vasopressin receptor binding
Biological Process:  activation of MAPK activity; apoptotic process; follicle-stimulating hormone signaling pathway; G protein-coupled receptor internalization; G protein-coupled receptor signaling pathway; histone acetylation; membrane organization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of GTPase activity; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; negative regulation of neuron apoptotic process; negative regulation of NF-kappaB transcription factor activity; negative regulation of Notch signaling pathway; negative regulation of protein ubiquitination; phototransduction; platelet activation; positive regulation of cell proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of ERK1 and ERK2 cascade; positive regulation of GTPase activity; positive regulation of histone acetylation; positive regulation of histone H4 acetylation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein binding; positive regulation of protein phosphorylation; positive regulation of protein ubiquitination; positive regulation of receptor internalization; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell apoptotic process; positive regulation of transcription by RNA polymerase II; proteasome-mediated ubiquitin-dependent protein catabolic process; protein transport; protein ubiquitination; response to drug; stress fiber assembly; transcription by RNA polymerase II; ubiquitin-dependent protein catabolic process
Reference #:  P49407-2 (UniProtKB)
Alt. Names/Synonyms: ARB1; ARR1; ARRB1; ARRB1 iso2; arrestin 2; arrestin beta 1; Arrestin beta-1; arrestin, beta 1; beta-arrestin; Beta-arrestin-1; Non-visual arrestin-2
Gene Symbols: ARRB1
Molecular weight: 46,309 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Hedgehog Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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ARRB1 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein