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neurabin 1
Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Protein phosphatase, regulatory subunit |
| Chromosomal Location of Human Ortholog: 6 A1|6 1.86 cM |
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Cellular Component:
actin cytoskeleton; cortical actin cytoskeleton; cytoplasm; cytoskeleton; cytosol; dendrite; dendritic spine; dendritic spine neck; filopodium; glutamatergic synapse; growth cone; growth cone lamellipodium; lamellipodium; neuromuscular junction; neuron projection; neuronal cell body; postsynaptic actin cytoskeleton; postsynaptic density; synapse
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Molecular Function:
actin filament binding; GTPase binding; ion channel binding; protein binding; protein C-terminus binding; protein domain specific binding; protein homodimerization activity; protein kinase binding; protein phosphatase 1 binding; protein-containing complex binding
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Biological Process:
actin filament organization; calcium-mediated signaling; cellular response to toxic substance; excitatory postsynaptic potential; modulation of chemical synaptic transmission; negative regulation of long-term synaptic potentiation; negative regulation of spontaneous neurotransmitter secretion; negative regulation of stress fiber assembly; neuron projection development; positive regulation of dendritic spine development; positive regulation of long-term synaptic depression; positive regulation of neuron projection development; positive regulation of protein kinase activity; postsynaptic actin cytoskeleton organization; regulation of actin filament polymerization; regulation of dendritic spine morphogenesis; regulation of filopodium assembly; regulation of synapse assembly; regulation of synapse structural plasticity
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Reference #:
Q7TN74
(UniProtKB)
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Alt. Names/Synonyms: 2810430P21Rik; 4930518N04Rik; 5330407E15; A230094E16Rik; BB181831; mKIAA1222; Neurabin; Neurabin I; neurabin-I; Neural tissue-specific F-actin binding protein; Ppp1r9a; protein phosphatase 1, regulatory (inhibitor) subunit 9A; Protein phosphatase 1, regulatory (Inhibitor) subunit 9A, isoform CRA_c
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Gene Symbols: Ppp1r9a
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Molecular weight:
122,955 Da
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Basal Isoelectric point:
5.05
Predict pI for various phosphorylation states
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