VASP Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. Belongs to the Ena/VASP family. Highly expressed in platelets. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component:  actin cytoskeleton; bicellular tight junction; cytosol; filopodium membrane; focal adhesion; lamellipodium membrane; plasma membrane
Molecular Function:  actin binding; profilin binding; protein binding; SH3 domain binding
Biological Process:  actin polymerization or depolymerization; axon guidance; cell junction assembly; neural tube closure; positive regulation of actin filament polymerization; protein homotetramerization
Reference #:  P50552 (UniProtKB)
Alt. Names/Synonyms: vasodilator stimulated phosphoprotein; Vasodilator-stimulated phosphoprotein; VASP
Gene Symbols: VASP
Molecular weight: 39,830 Da
Basal Isoelectric point: 9.05  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VASP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene