H1T Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. Belongs to the histone H1/H5 family. Testis-specific. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 13|13 A3.1
Cellular Component:  chromosome; condensed nuclear chromosome; intracellular anatomical structure; nucleosome; nucleus
Molecular Function:  DNA binding; double-stranded DNA binding; nucleosomal DNA binding; structural constituent of chromatin
Biological Process:  binding of sperm to zona pellucida; cell differentiation; chromosome condensation; flagellated sperm motility; multicellular organism development; negative regulation of DNA recombination; nucleosome assembly; spermatogenesis
Reference #:  Q07133 (UniProtKB)
Alt. Names/Synonyms: H1 histone family, member T (testis-specific); H1-6; H1.6; H1.6 linker histone, cluster member; H1f6; H1ft; H1t; Hist1h; Hist1h1t; histone 1, H1t; histone cluster 1, H1t; Histone H1t; OTTMUSP00000000525; Testicular H1 histone
Gene Symbols: H1f6
Molecular weight: 21,540 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene