H1T Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. Belongs to the histone H1/H5 family. Testis-specific. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.2
Cellular Component:  nucleosome
Biological Process:  cell differentiation; multicellular organism development; nucleosome assembly
Reference #:  P22492 (UniProtKB)
Alt. Names/Synonyms: dJ221C16.2; H1 histone family, member T (testis-specific); H1-6; H1.6; H1.6 linker histone, cluster member; H1FT; H1T; HIST1H1T; histone 1, H1t; histone cluster 1 H1 family member t; histone cluster 1, H1t; Histone H1t; MGC163222; Testicular H1 histone
Gene Symbols: H1-6
Molecular weight: 22,019 Da
Basal Isoelectric point: 11.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene