SFRP5 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. Belongs to the secreted frizzled-related protein (sFRP) family. Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 19|19 C3
Cellular Component:  extracellular region; extracellular space
Molecular Function:  Wnt-protein binding
Biological Process:  canonical Wnt signaling pathway; cell differentiation; convergent extension involved in axis elongation; digestive tract morphogenesis; multicellular organism development; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of JUN kinase activity; negative regulation of planar cell polarity pathway involved in axis elongation; negative regulation of protein kinase B signaling; negative regulation of Wnt signaling pathway; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis; non-canonical Wnt signaling pathway; planar cell polarity pathway involved in neural tube closure; post-anal tail morphogenesis; regulation of BMP signaling pathway; regulation of establishment of planar polarity; regulation of Wnt signaling pathway; Wnt signaling pathway
Reference #:  Q9WU66 (UniProtKB)
Alt. Names/Synonyms: AI605071; OTTMUSP00000023386; SARP3; Secreted frizzled-related protein 5; secreted frizzled-related sequence protein 5; sFRP-5; Sfrp5
Gene Symbols: Sfrp5
Molecular weight: 35,382 Da
Basal Isoelectric point: 8.91  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene