SFRP5 Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. Belongs to the secreted frizzled-related protein (sFRP) family. Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 10q24.2
Cellular Component:  extracellular space
Molecular Function:  Wnt-protein binding
Biological Process:  anatomical structure morphogenesis; apoptotic process; canonical Wnt signaling pathway; cell differentiation; establishment or maintenance of cell polarity; negative regulation of canonical Wnt signaling pathway; negative regulation of cell population proliferation; negative regulation of DNA-binding transcription factor activity; negative regulation of protein kinase B signaling; negative regulation of Wnt signaling pathway; negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis; non-canonical Wnt signaling pathway; signal transduction; visual perception
Reference #:  Q5T4F7 (UniProtKB)
Alt. Names/Synonyms: Frizzled-related protein 1b; FRP-1b; FRP1B; SARP-3; SARP3; secreted apoptosis related protein 3; Secreted apoptosis-related protein 3; secreted frizzled related protein 5; Secreted frizzled-related protein 5; sFRP-5; SFRP5
Gene Symbols: SFRP5
Molecular weight: 35,563 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein