UGDH Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans. Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. Detected in heart, placenta, liver, pancreas, spleen, thymus, prostate, ovary, small intestine and colon (PubMed:9737970). Widely expressed (PubMed:9737970). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Motility/polarity/chemotaxis; Oxidoreductase
Chromosomal Location of human Ortholog: 4p14
Cellular Component:  cytosol; nucleoplasm; nucleus
Molecular Function:  identical protein binding; NAD binding; UDP-glucose 6-dehydrogenase activity
Biological Process:  carbohydrate metabolic process; chondroitin sulfate biosynthetic process; gastrulation with mouth forming second; glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process; neuron development; protein hexamerization; UDP-glucuronate biosynthetic process
Disease: Epileptic Encephalopathy, Early Infantile, 84
Reference #:  O60701 (UniProtKB)
Alt. Names/Synonyms: EIEE84; GDH; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogenase; UDPGDH; UGD; UGDH; uridine diphospho-glucose dehydrogenase
Gene Symbols: UGDH
Molecular weight: 55,024 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
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UGDH

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein