TH an enzyme involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. Four splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  cytoplasm; cytoplasmic side of plasma membrane; cytoplasmic vesicle; cytosol; dendrite; melanosome membrane; mitochondrion; neuron projection; nucleus; perikaryon; smooth endoplasmic reticulum; synaptic vesicle; terminal bouton
Molecular Function:  amino acid binding; dopamine binding; enzyme binding; ferric iron binding; ferrous iron binding; oxygen binding; protein binding; protein domain specific binding; tetrahydrobiopterin binding; tyrosine 3-monooxygenase activity
Biological Process:  aminergic neurotransmitter loading into synaptic vesicle; anatomical structure morphogenesis; animal organ morphogenesis; catecholamine biosynthetic process; cellular response to alkaloid; cellular response to glucose stimulus; cellular response to growth factor stimulus; cellular response to manganese ion; cellular response to nicotine; cerebral cortex development; circadian sleep/wake cycle; dopamine biosynthetic process; dopamine biosynthetic process from tyrosine; eating behavior; embryonic camera-type eye morphogenesis; epinephrine biosynthetic process; eye photoreceptor cell development; fatty acid metabolic process; glycoside metabolic process; heart development; heart morphogenesis; isoquinoline alkaloid metabolic process; learning; locomotory behavior; mating behavior; memory; multicellular organism aging; neurotransmitter biosynthetic process; norepinephrine biosynthetic process; oxidation-reduction process; phthalate metabolic process; phytoalexin metabolic process; pigmentation; regulation of heart contraction; response to activity; response to amphetamine; response to corticosterone; response to electrical stimulus; response to estradiol; response to ethanol; response to ether; response to herbicide; response to hypoxia; response to immobilization stress; response to isolation stress; response to light stimulus; response to lipopolysaccharide; response to nutrient levels; response to peptide hormone; response to pyrethroid; response to salt stress; response to water deprivation; response to zinc ion; sensory perception of sound; social behavior; sphingolipid metabolic process; synaptic transmission, dopaminergic; terpene metabolic process; visual perception
Disease: Segawa Syndrome, Autosomal Recessive
Reference #:  P07101 (UniProtKB)
Alt. Names/Synonyms: dystonia 14; DYT14; DYT5b; HTH-2; TH; TH2; TY3H; TYH; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase; tyrosine hydroxylase
Gene Symbols: TH
Molecular weight: 58,600 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TH

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein