SCP2 Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. In the N-terminal section; belongs to the thiolase-like superfamily. Thiolase family. Liver, fibroblasts, and placenta. 8 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - primary bile acid biosynthesis; Lipid-binding; Mitochondrial; Transferase
Chromosomal Location of human Ortholog: 1p32.3
Cellular Component:  cytosol; intracellular membrane-bounded organelle; mitochondrion; nucleoplasm; peroxisomal matrix; peroxisome; protein-containing complex
Molecular Function:  cholesterol binding; fatty-acyl-CoA binding; long-chain fatty acyl-CoA binding; oleic acid binding; propanoyl-CoA C-acyltransferase activity; propionyl-CoA C2-trimethyltridecanoyltransferase activity; protein binding; signaling receptor binding
Biological Process:  alpha-linolenic acid metabolic process; bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; lipid hydroperoxide transport; positive regulation of intracellular cholesterol transport; protein targeting to peroxisome
Disease: Leukoencephalopathy With Dystonia And Motor Neuropathy
Reference #:  P22307 (UniProtKB)
Alt. Names/Synonyms: DKFZp686C12188; DKFZp686D11188; epididymis secretory sperm binding protein; NLTP; Non-specific lipid-transfer protein; nonspecific lipid-transfer protein; NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-2; SCP-chi; SCP-X; SCP2; SCPX; Sterol carrier protein 2; Sterol carrier protein X
Gene Symbols: SCP2
Molecular weight: 58,994 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein