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THAP7
Chromatin-associated, histone tail-binding protein that represses transcription via recruitment of HDAC3 and nuclear hormone receptor corepressors. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 22q11.21 |
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Cellular Component:
chromatin; intracellular membrane-bounded organelle; nuclear membrane; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
C2H2 zinc finger domain binding; DNA binding; general transcription initiation factor binding; histone binding; histone deacetylase binding; identical protein binding; lysine-acetylated histone binding; metal ion binding; methylated histone binding; phosphorylated histone binding; protein binding; transcription corepressor binding
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Biological Process:
negative regulation of DNA-templated transcription; negative regulation of histone acetylation; negative regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
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Reference #:
Q9BT49
(UniProtKB)
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Alt. Names/Synonyms: MGC10963; THAP domain containing 7; THAP domain-containing protein 7; THAP7
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Gene Symbols: THAP7
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Molecular weight:
34,414 Da
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Basal Isoelectric point:
9.54
Predict pI for various phosphorylation states
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