ADAMTS12
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. Expressed in skeletal muscle and fat. Detected at significant levels in fetal lung. Widely expressed in gastric carcinomas and in cancer cells of diverse origin. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 5p13.3-p13.2 |
Cellular Component:
extracellular matrix; extracellular region
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Molecular Function:
metal ion binding; metalloendopeptidase activity; protein binding
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Biological Process:
cell migration; cell-matrix adhesion; cellular response to BMP stimulus; cellular response to interleukin-1; cellular response to tumor necrosis factor; chondrocyte differentiation; collagen fibril organization; extracellular matrix organization; negative regulation of cellular response to hepatocyte growth factor stimulus; negative regulation of cellular response to vascular endothelial growth factor stimulus; negative regulation of chondrocyte differentiation; negative regulation of hepatocyte growth factor receptor signaling pathway; ossification involved in bone maturation; proteoglycan catabolic process; proteolysis; proteolysis involved in protein catabolic process; regulation of endothelial tube morphogenesis; regulation of inflammatory response
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Reference #:
P58397
(UniProtKB)
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Alt. Names/Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; ADAM metallopeptidase with thrombospondin type 1 motif 12; ADAM metallopeptidase with thrombospondin type 1 motif, 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12; ADAMTS12; ATS12; PRO4389
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Gene Symbols: ADAMTS12
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Molecular weight:
177,676 Da
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Basal Isoelectric point:
8.25
Predict pI for various phosphorylation states
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