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GSC
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of mouse Ortholog: 12 E|12 54.32 cM |
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Cellular Component:
nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding
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Biological Process:
anatomical structure morphogenesis; dorsal/ventral neural tube patterning; ear development; embryonic skeletal system morphogenesis; forebrain development; middle ear morphogenesis; multicellular organism development; muscle organ morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; neural crest cell fate specification; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; signal transduction involved in regulation of gene expression; Wnt signaling pathway
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Reference #:
Q02591
(UniProtKB)
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Alt. Names/Synonyms: goos; goosecoid homeobox; Gsc; Homeobox protein goosecoid; OTTMUSP00000023890
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Gene Symbols: Gsc
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Molecular weight:
27,980 Da
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Basal Isoelectric point:
8.86
Predict pI for various phosphorylation states
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