GSC Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 12 E|12 54.32 cM
Cellular Component:  nuclear body; nucleus; transcription factor complex
Molecular Function:  DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding
Biological Process:  anatomical structure morphogenesis; dorsal/ventral neural tube patterning; ear development; embryonic skeletal system morphogenesis; forebrain development; middle ear morphogenesis; multicellular organism development; muscle organ morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; neural crest cell fate specification; regulation of transcription, DNA-templated; signal transduction involved in regulation of gene expression
Reference #:  Q02591 (UniProtKB)
Alt. Names/Synonyms: goos; goosecoid homeobox; Gsc; Homeobox protein goosecoid; OTTMUSP00000023890
Gene Symbols: Gsc
Molecular weight: 27,980 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene