GSC Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component:  nuclear body; nucleus; transcription factor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding
Biological Process:  dorsal/ventral neural tube patterning; embryonic skeletal system morphogenesis; forebrain development; gastrulation; middle ear morphogenesis; muscle organ morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; neural crest cell fate specification; signal transduction involved in regulation of gene expression
Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
Reference #:  P56915 (UniProtKB)
Alt. Names/Synonyms: goosecoid homeobox; GSC; Homeobox protein goosecoid
Gene Symbols: GSC
Molecular weight: 28,150 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB