GSC Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals. Belongs to the paired homeobox family. Bicoid subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component:  nuclear body; nucleus; transcription factor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II repressing transcription factor binding; RNA polymerase II transcription factor binding
Biological Process:  dorsal/ventral neural tube patterning; embryonic skeletal system morphogenesis; forebrain development; gastrulation; middle ear morphogenesis; muscle organ morphogenesis; negative regulation of transcription by RNA polymerase II; negative regulation of Wnt signaling pathway; neural crest cell fate specification; signal transduction involved in regulation of gene expression
Disease: Short Stature, Auditory Canal Atresia, Mandibular Hypoplasia, And Skeletal Abnormalities
Reference #:  P56915 (UniProtKB)
Alt. Names/Synonyms: goosecoid homeobox; GSC; Homeobox protein goosecoid; SAMS
Gene Symbols: GSC
Molecular weight: 28,150 Da
Basal Isoelectric point: 8.86  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB