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ACOX1
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. Belongs to the acyl-CoA oxidase family. Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.3.3.6; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase |
| Chromosomal Location of Human Ortholog: 11|11 E2 |
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Cellular Component:
cytoplasm; intracellular membrane-bounded organelle; nucleolus; nucleoplasm; nucleus; peroxisomal membrane; peroxisome; plasma membrane
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Molecular Function:
acyl-CoA oxidase activity; FAD binding; fatty acid binding; flavin adenine dinucleotide binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-CH group of donors; palmitoyl-CoA oxidase activity; PDZ domain binding; protein homodimerization activity; protein N-terminus binding; signaling receptor binding
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Biological Process:
cholesterol homeostasis; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid metabolic process; fatty acid oxidation; generation of precursor metabolites and energy; lipid homeostasis; lipid metabolic process; peroxisome fission; prostaglandin metabolic process; spermatogenesis; very long-chain fatty acid metabolic process
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Reference #:
Q9R0H0
(UniProtKB)
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Alt. Names/Synonyms: Acox; Acox1; Acyl-CoA oxidase; acyl-Coenzyme A oxidase 1, palmitoyl; AI042784; AOX; D130055E20Rik; OTTMUSP00000003995; Palmitoyl-CoA oxidase; Paox; Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain; Peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-coenzyme A oxidase; peroxisomal straight-chain Acyl-CoA oxidase
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Gene Symbols: Acox1
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Molecular weight:
74,649 Da
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Basal Isoelectric point:
8.64
Predict pI for various phosphorylation states
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