ACOX1
Catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. Isoform 1 shows highest activity against medium-chain fatty acyl-CoAs and activity decreases with increasing chain length. Isoform 2 is active against a much broader range of substrates and shows activity towards very long-chain acyl-CoAs. Isoform 2 is twice as active as isoform 1 against 16-hydroxy-palmitoyl-CoA and is 25% more active against 1,16-hexadecanodioyl-CoA. Belongs to the acyl-CoA oxidase family. Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: EC 1.3.3.6; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase |
Chromosomal Location of human Ortholog: 17q25.1 |
Cellular Component:
cytosol; peroxisomal matrix; peroxisomal membrane; peroxisome
|
Molecular Function:
acyl-CoA oxidase activity; FAD binding; fatty acid binding; flavin adenine dinucleotide binding; palmitoyl-CoA oxidase activity; PDZ domain binding; protein binding; protein homodimerization activity
|
Biological Process:
fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid catabolic process; fatty acid oxidation; generation of precursor metabolites and energy; hydrogen peroxide biosynthetic process; lipid homeostasis; lipid metabolic process; prostaglandin metabolic process; spermatogenesis; very long-chain fatty acid beta-oxidation; very long-chain fatty acid metabolic process
|
Disease: Mitchell Syndrome; Peroxisomal Acyl-coa Oxidase Deficiency
|
Reference #:
Q15067
(UniProtKB)
|
Alt. Names/Synonyms: ACOX; ACOX1; acyl-CoA oxidase 1; acyl-CoA oxidase 1, palmitoyl; acyl-CoA oxidase, straight-chain; acyl-Coenzyme A oxidase 1, palmitoyl; AOX; MGC1198; MITCH; PALMCOX; Palmitoyl-CoA oxidase; Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain; Peroxisomal acyl-coenzyme A oxidase 1; peroxisomal fatty acyl-CoA oxidase; SCOX; Straight-chain acyl-CoA oxidase
|
Gene Symbols: ACOX1
|
Molecular weight:
74,424 Da
|
Basal Isoelectric point:
8.35
Predict pI for various phosphorylation states
|