TRF1 Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Highly expressed and ubiquitous. Isoform Pin2 predominates. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 8q21.11
Cellular Component:  cytoplasm; fibrillar center; nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; shelterin complex; spindle
Molecular Function:  ankyrin repeat binding; DNA binding; DNA binding, bending; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded telomeric DNA binding; G-rich strand telomeric DNA binding; protein binding; protein homodimerization activity; telomeric DNA binding
Biological Process:  cell division; meiotic telomere clustering; negative regulation of DNA replication; negative regulation of establishment of protein localization to telomere; negative regulation of establishment of protein-containing complex localization to telomere; negative regulation of establishment of RNA localization to telomere; negative regulation of exonuclease activity; negative regulation of telomerase activity; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomere lengthening; negative regulation of telomeric D-loop disassembly; positive regulation of shelterin complex assembly; regulation of transcription by RNA polymerase II; response to drug; t-circle formation; telomere capping; telomere maintenance; telomere maintenance via telomerase; telomeric D-loop disassembly
Reference #:  P54274 (UniProtKB)
Alt. Names/Synonyms: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1
Gene Symbols: TERF1
Molecular weight: 50,246 Da
Basal Isoelectric point: 5.99  Predict pI for various phosphorylation states
Select Structure to View Below

TRF1

Protein Structure Not Found.


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