|
TRF1
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Highly expressed and ubiquitous. Isoform Pin2 predominates. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: DNA-binding |
| Chromosomal Location of human Ortholog: 8q21.11 |
|
Cellular Component:
chromosome, telomeric region; cytoplasm; fibrillar center; nuclear body; nuclear telomere cap complex; nucleolus; nucleoplasm; nucleus; shelterin complex; spindle
|
|
Molecular Function:
ankyrin repeat binding; DNA binding; DNA binding, bending; double-stranded telomeric DNA binding; G-rich strand telomeric DNA binding; identical protein binding; microtubule binding; molecular adaptor activity; protein binding; protein homodimerization activity; telomerase activity; telomeric DNA binding
|
|
Biological Process:
cell division; meiotic telomere clustering; negative regulation of DNA replication; negative regulation of establishment of protein localization to telomere; negative regulation of establishment of protein-containing complex localization to telomere; negative regulation of establishment of RNA localization to telomere; negative regulation of exonuclease activity; negative regulation of telomerase activity; negative regulation of telomere maintenance via semi-conservative replication; negative regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomere lengthening; negative regulation of telomeric D-loop disassembly; positive regulation of shelterin complex assembly; positive regulation of telomere maintenance; response to xenobiotic stimulus; t-circle formation; telomere capping; telomere maintenance; telomere maintenance via telomerase; telomeric D-loop disassembly
|
|
Reference #:
P54274
(UniProtKB)
|
|
Alt. Names/Synonyms: FLJ41416; hTRF1-AS; NIMA-interacting protein 2; PIN2; t-TRF1; Telomeric protein Pin2/TRF1; telomeric repeat binding factor (NIMA-interacting) 1; telomeric repeat binding factor 1; telomeric repeat binding protein 1; Telomeric repeat-binding factor 1; TERF1; TRBF1; TRF; TRF1; TTAGGG repeat-binding factor 1
|
|
Gene Symbols: TERF1
|
|
Molecular weight:
50,246 Da
|
|
Basal Isoelectric point:
5.99
Predict pI for various phosphorylation states
|
