VEGF iso14 Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Belongs to the PDGF/VEGF growth factor family. Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland. 17 human isoforms generated by alternative promoter usage, alternative splicing or alternative initiation have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 6p21.1
Cellular Component:  cell surface; cytoplasm; extracellular matrix; extracellular region; extracellular space; membrane; platelet alpha granule lumen; secretory granule
Molecular Function:  chemoattractant activity; cytokine activity; extracellular matrix binding; fibronectin binding; growth factor activity; heparin binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor ligand activity; vascular endothelial growth factor receptor 1 binding; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor binding
Biological Process:  activation of protein kinase activity; angiogenesis; artery morphogenesis; branching involved in blood vessel morphogenesis; branching morphogenesis of an epithelial tube; camera-type eye morphogenesis; cardiac muscle fiber development; cardiac vascular smooth muscle cell development; cell maturation; cell migration involved in sprouting angiogenesis; cellular response to hypoxia; cellular response to vascular endothelial growth factor stimulus; cellular stress response to acid chemical; commissural neuron axon guidance; coronary artery morphogenesis; coronary vein morphogenesis; cytokine-mediated signaling pathway; dopaminergic neuron differentiation; endothelial cell chemotaxis; epithelial cell differentiation; eye photoreceptor cell development; heart morphogenesis; in utero embryonic development; induction of positive chemotaxis; kidney development; lactation; lung development; lymph vessel morphogenesis; macrophage differentiation; mammary gland alveolus development; mesoderm development; monocyte differentiation; motor neuron migration; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; nervous system development; outflow tract morphogenesis; ovarian follicle development; platelet degranulation; positive chemotaxis; positive regulation of angiogenesis; positive regulation of axon extension involved in axon guidance; positive regulation of blood vessel endothelial cell migration; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of cell adhesion; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell proliferation; positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway; positive regulation of cellular component movement; positive regulation of cold-induced thermogenesis; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of focal adhesion assembly; positive regulation of gene expression; positive regulation of histone deacetylase activity; positive regulation of leukocyte migration; positive regulation of MAP kinase activity; positive regulation of mesenchymal cell proliferation; positive regulation of neuroblast proliferation; positive regulation of p38MAPK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine autophosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein autophosphorylation; positive regulation of protein complex assembly; positive regulation of protein kinase C signaling; positive regulation of protein kinase D signaling; positive regulation of protein phosphorylation; positive regulation of receptor internalization; positive regulation of retinal ganglion cell axon guidance; positive regulation of sprouting angiogenesis; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of vascular endothelial growth factor receptor signaling pathway; post-embryonic camera-type eye development; primitive erythrocyte differentiation; regulation of cell shape; regulation of nitric oxide mediated signal transduction; regulation of retinal ganglion cell axon guidance; regulation of signaling receptor activity; regulation of transcription by RNA polymerase II; regulation of transcription from RNA polymerase II promoter in response to hypoxia; response to hypoxia; surfactant homeostasis; tube formation; vascular endothelial growth factor receptor signaling pathway; vasculogenesis; VEGF-activated neuropilin signaling pathway
Disease: Microvascular Complications Of Diabetes, Susceptibility To, 1
Reference #:  P15692-14 (UniProtKB)
Alt. Names/Synonyms: MGC70609; MVCD1; Vascular endothelial growth factor A; vascular endothelial growth factor A121; vascular endothelial growth factor A165; Vascular permeability factor; VEGF; VEGF iso14; VEGF-A; VEGFA; VPF
Gene Symbols: VEGFA
Molecular weight: 45,467 Da
Basal Isoelectric point: 9.22  Predict pI for various phosphorylation states
CST Pathways:  Angiogenesis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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VEGF iso14

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene