GLB1
Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. Belongs to the glycosyl hydrolase 35 family. Detected in placenta (at protein level) (PubMed:8383699). Detected in fibroblasts and testis (PubMed:2511208). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Carbohydrate Metabolism - galactose; EC 3.2.1.23; Glycan Metabolism - glycosaminoglycan degradation; Glycan Metabolism - glycosphingolipid biosynthesis - ganglio series; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid |
Chromosomal Location of mouse Ortholog: 9 F3|9 64.4 cM |
Cellular Component:
cytoplasm; extracellular space; Golgi apparatus; intracellular membrane-bounded organelle; lysosome; vacuole
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Molecular Function:
beta-galactosidase activity; galactoside binding; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hydrolase activity, hydrolyzing O-glycosyl compounds; protein homodimerization activity
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Biological Process:
carbohydrate metabolic process; galactose catabolic process; metabolic process
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Reference #:
P23780
(UniProtKB)
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Alt. Names/Synonyms: Acid beta-galactosidase; AW125515; Beta-galactosidase; beta-galactosidase complex; beta-galactosidase electrophoretic; beta-galactosidase systemic regulator; beta-galactosidase temporal; BGAL; Bge; Bgl; Bgl-; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; galactosidase, beta 1; Glb-1; Glb1; Lactase
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Gene Symbols: Glb1
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Molecular weight:
73,121 Da
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Basal Isoelectric point:
7.15
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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