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ALDH2
Belongs to the aldehyde dehydrogenase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation |
| Chromosomal Location of mouse Ortholog: 5|5 F |
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Cellular Component:
mitochondrial matrix
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Molecular Function:
aldehyde dehydrogenase (NAD+) activity; carboxylesterase activity; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity; identical protein binding; NAD binding; NADH binding; nitroglycerin reductase activity; oxidoreductase activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; protein binding
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Biological Process:
acetaldehyde metabolic process; aldehyde catabolic process; behavioral response to ethanol; cellular detoxification of aldehyde; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of apoptotic process; regulation of dopamine biosynthetic process; regulation of reactive oxygen species metabolic process; regulation of serotonin biosynthetic process; response to organic cyclic compound
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Reference #:
P47738
(UniProtKB)
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Alt. Names/Synonyms: Ahd; Ahd-; Ahd-1; Ahd-5; AHD-M1; Ahd1; Ahd5; aldehyde dehydrogenase 2, mitochondrial; Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; Aldh2; ALDHI; OTTMUSP00000027439
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Gene Symbols: Aldh2
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Molecular weight:
56,538 Da
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Basal Isoelectric point:
7.53
Predict pI for various phosphorylation states
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