MARCH4 E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Expressed in brain and placenta. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1|1 C3
Cellular Component:  Golgi apparatus; Golgi stack; integral component of membrane; membrane; trans-Golgi network
Molecular Function:  metal ion binding; transferase activity; ubiquitin-protein transferase activity; zinc ion binding
Reference #:  Q80TE3 (UniProtKB)
Alt. Names/Synonyms: BC056494; E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4; Kiaa1399; Marc; MARCH-IV; March4; Marchf4; MARH4; membrane associated ring-CH-type finger 4; membrane-associated ring finger (C3HC4) 4; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; mKIAA1399; RING-type E3 ubiquitin transferase MARCH4; RING-type E3 ubiquitin transferase MARCHF4
Gene Symbols: March4
Molecular weight: 45,201 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene