|
MARCH4
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Expressed in brain and placenta. Note: This description may include information from UniProtKB.
|
| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 2q35 |
|
Cellular Component:
Golgi membrane; Golgi stack; trans-Golgi network
|
|
Molecular Function:
ubiquitin-protein transferase activity; zinc ion binding
|
|
Biological Process:
protein ubiquitination
|
|
Reference #:
Q9P2E8
(UniProtKB)
|
|
Alt. Names/Synonyms: E3 ubiquitin-protein ligase MARCH4; E3 ubiquitin-protein ligase MARCHF4; KIAA1399; MARCH-IV; MARCH4; MARCHF4; MARH4; membrane associated ring finger 4; membrane associated ring-CH-type finger 4; membrane-associated ring finger (C3HC4) 4; membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase; Membrane-associated RING finger protein 4; Membrane-associated RING-CH protein IV; MGC104908; RING finger protein 174; RING-type E3 ubiquitin transferase MARCH4; RING-type E3 ubiquitin transferase MARCHF4; RNF174
|
|
Gene Symbols: MARCHF4
|
|
Molecular weight:
45,528 Da
|
|
Basal Isoelectric point:
8.18
Predict pI for various phosphorylation states
|
